Genetics of coronary artery disease: discovery, biology and clinical translation.

TitleGenetics of coronary artery disease: discovery, biology and clinical translation.
Publication TypeJournal Article
Year of Publication2017
AuthorsKhera, AV, Kathiresan, S
JournalNat Rev Genet
Volume18
Issue6
Pagination331-344
Date Published2017 06
ISSN1471-0064
KeywordsAnimals, Coronary Artery Disease, Humans, Precision Medicine, Translational Medical Research
Abstract

Coronary artery disease is the leading global cause of mortality. Long recognized to be heritable, recent advances have started to unravel the genetic architecture of the disease. Common variant association studies have linked approximately 60 genetic loci to coronary risk. Large-scale gene sequencing efforts and functional studies have facilitated a better understanding of causal risk factors, elucidated underlying biology and informed the development of new therapeutics. Moving forwards, genetic testing could enable precision medicine approaches by identifying subgroups of patients at increased risk of coronary artery disease or those with a specific driving pathophysiology in whom a therapeutic or preventive approach would be most useful.

DOI10.1038/nrg.2016.160
Alternate JournalNat Rev Genet
PubMed ID28286336
PubMed Central IDPMC5935119
Grant ListKL2 TR001100 / TR / NCATS NIH HHS / United States
R01 HL127564 / HL / NHLBI NIH HHS / United States
UM1 HG008895 / HG / NHGRI NIH HHS / United States