Genetic association studies in cardiovascular diseases: Do we have enough power?

TitleGenetic association studies in cardiovascular diseases: Do we have enough power?
Publication TypeJournal Article
Year of Publication2017
AuthorsAuer, PL, Stitziel, NO
JournalTrends Cardiovasc Med
Date Published2017 08
KeywordsCardiovascular Diseases, Data Accuracy, Data Interpretation, Statistical, Genetic Association Studies, Genetic Markers, Genetic Predisposition to Disease, Genetic Variation, Humans, Phenotype, Reproducibility of Results, Research Design, Risk Assessment, Risk Factors

Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research in human genetics has enriched our understanding of the pathobiology of CVD. As these studies continue to expand, the issue of statistical power plays an important role in study design as well as the interpretation of results. We provide an overview of the component parts that determine statistical power and preview the future of CVD genetic association studies through this lens.

Alternate JournalTrends Cardiovasc Med
PubMed ID28456354
PubMed Central IDPMC5642948
Grant ListK08 HL114642 / HL / NHLBI NIH HHS / United States
R01 HL131961 / HL / NHLBI NIH HHS / United States
UM1 HG008853 / HG / NHGRI NIH HHS / United States