dbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.

TitledbMTS: A comprehensive database of putative human microRNA target site SNVs and their functional predictions.
Publication TypeJournal Article
Year of Publication2020
AuthorsLi, C, Mou, C, Swartz, MD, Yu, B, Bai, Y, Tu, Y, Liu, X
JournalHum Mutat
Volume41
Issue6
Pagination1123-1130
Date Published2020 Jun
ISSN1098-1004
Abstract

MicroRNAs (miRNA) are short noncoding RNAs that can repress the expression of protein-coding messenger RNAs (mRNAs) by binding to the 3'-untranslated region (UTR) of the target. Genetic mutations such as single nucleotide variants (SNVs) in the 3'-UTR of the mRNAs can disrupt miRNA regulation. In this study, we presented dbMTS, a database for miRNA target site (MTS) SNVs and their functional annotations. This database can help studies easily identify putative SNVs that affect miRNA targeting and facilitate the prioritization of their functional importance. dbMTS is freely available for academic use at http://database.liulab.science/dbMTS as a web service or a downloadable attached database of dbNSFP.

DOI10.1002/humu.24020
Alternate JournalHum. Mutat.
PubMed ID32227657
PubMed Central IDPMC7251985
Grant ListUM1 HG008898 / HG / NHGRI NIH HHS / United States
1UM1HG008898 / HG / NHGRI NIH HHS / United States