Centers for Common Disease Genomics

Centers for Common Disease Genomics (CCDG)

The Centers for Common Disease Genomics (CCDG) are a collaborative large-scale genome sequencing effort comprehensively identifying rare risk and protective variants that contribute to multiple common disease phenotypes. The initial focus of the CCDGs is in cardiovascular disease (early onset heart disease, hemorrhagic stroke) and neuropsychiatric disease (autism). Additional example diseases will be considered in future years of the project.

• Undertake variant discovery for enough different examples of disease architectures and study designs to better understand the general principles of genomic architecture underlying common, complex inherited diseases.
• Understand how best to design rare variant studies for common disease.
• Develop resources, informatics tools, and innovative approaches and technologies for multiple disease research communities and the wider biomedical research community.

The currently funded CCDG are at Baylor College of Medicine Human Genome Sequencing Center, The Broad Institute, New York Genome Center, and The McDonnell Genome Institute at Washington University.

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